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Brokers with an impact on hepatic cytochrome P450 pathways or conjugation can change the rate of diazepam metabolism. These interactions would be expected to get most significant with lengthy-time period diazepam therapy, and their scientific importance is variable.[28]
Delayed elimination has also been described for that Energetic metabolite desmethyldiazepam . Benzodiazepines are generally implicated in hepatic encephalopathy . Will increase in 50 percent-existence have also been claimed in hepatic fibrosis and in the two acute and Serious hepatitis .
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